Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10586336 | 0.84 | AHR (0.49) | AHRPDE10AKDM4EALDH1A1POLB | |
| SCHEMBL17221691 | 0.82 | AHR (0.51) | AHRPDE10AKDM4EALDH1A1POLB | |
| SCHEMBL17221587 | 0.82 | AHR (0.47) | AHRPDE10AKDM4EALDH1A1POLB | |
| SCHEMBL31132638 | 0.75 | AKR1B1 (0.36) | PDE10AKDM4EALDH1A1POLBNPC1 | |
| SCHEMBL20602495 | 0.74 | MME (0.35) | AHRPDE10AKDM4EALDH1A1NOTUM | |
| SCHEMBL21355823 | 0.73 | KLKB1 (0.39) | PDE10ACYP2C9 | |
| SCHEMBL15607692 | 0.73 | PDE10A (0.41) | AHRPDE10AKDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL15549536 | 0.72 | PDE10A (0.40) | AHRPDE10AKDM4EALDH1A1POLB | |
| SCHEMBL15415685 | 0.72 | AHR (0.51) | AHRPDE10AKDM4EALDH1A1HTR1A | |
| SCHEMBL10271997 | 0.72 | AHR (0.51) | AHRPDE10AKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0322153-A2 | Heterocyclic oxophtalazinyl acetic acids | PFIZER INC. (US) | 1989-06-28 | — | — | EP | disclosed |