Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | THPO | P40225 | 1/20 | 0.80 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.78 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.71 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.71 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6455299 | 0.95 | HIF1A (0.87) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL30648615 | 0.95 | HIF1A (0.87) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL9698949 | 0.94 | HIF1A (0.85) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL4661064 | 0.94 | HIF1A (0.85) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| Hydrochloric Acid SCHEMBL10464260 | 0.94 | HIF1A (0.85) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL9085813 | 0.92 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL9089580 | 0.92 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL9089904 | 0.92 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL9085808 | 0.92 | HIF1A (0.81) | HIF1AMEN1KMT2AMAPTCYP1A2 | |
| SCHEMBL6455316 | 0.91 | MAPT (0.80) | HIF1AMEN1KMT2AMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3966948-A | Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods | BAYER AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | claimed |
| EP-0096299-B1 | HYDROXYIMINO AND ALKOXYIMINO DERIVATIVES OF 1,4-DIHYDROPYRIDINE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION THEREFROM | Pierrel S.p.A. (IT) | 1989-02-01 | — | — | EP | disclosed |
| US-4508719-A | Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine and anti-hypertensive compositions | PIERREL S.P.A. (IT) | 1985-04-02 | — | — | US | disclosed |
| EP-0096299-A2 | Hydroxyimino and alkoxyimino derivatives of 1,4-dihydropyridine, process for the preparation thereof and pharmaceutical composition therefrom | Pierrel S.p.A. (IT) | 1983-12-21 | — | — | EP | disclosed |
| US-3966948-A | Spasmolytic, vaso-dilating and anti-hypertensive compositions and methods | BAYER AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | disclosed |