Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | RECQL | P46063 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | BLM | P54132 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | MTOR | P42345 | 4/20 | 0.70 |
| ▸ | APEX1 | P27695 | 3/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | THPO | P40225 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL5553020 | 0.93 | TDP1 (0.67) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL29525823 | 0.93 | TDP1 (0.65) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL241136 | 0.93 | TDP1 (0.65) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL6561416 | 0.84 | TDP1 (0.57) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL30516160 | 0.84 | TDP1 (0.67) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL278495 | 0.84 | TDP1 (0.67) | TDP1KDM4EMAPTRECQLLMNA | |
| SCHEMBL14293022 | 0.84 | TDP1 (0.67) | TDP1KDM4EMAPTRECQLLMNA | |
| Formic Acid SCHEMBL29183960 | 0.83 | TDP1 (0.55) | TDP1KDM4EMAPTRECQLLMNA | |
| Acetic Acid SCHEMBL28397274 | 0.83 | TDP1 (0.55) | TDP1KDM4EMAPTRECQLLMNA | |
| Levonordefrin SCHEMBL119171 | 0.83 | TDP1 (1.00) | TDP1KDM4EMAPTRECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167204-B1 | METHOD FOR IMPROVING THE ABSORPTION AND EFFECTIVENESS OF A CATECHOLAMINE COMPOUND | SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) | 1989-09-27 | — | — | EP | disclosed |
| US-4673671-A | CONVERSION TO MONO O-PHOSPHATE ESTER | SIMES SOCIETA ITALIANA MEDICINALI E SINTETICI S.P.A. (IT) | 1987-06-16 | — | — | US | disclosed |
| EP-0167204-A1 | Method for improving the absorption and effectiveness of a catecholamine compound | SIMES S.p.A. Società Italiana Medicinali e Sintetici (IT) | 1986-01-08 | — | — | EP | disclosed |