Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366330 | 1.00 | KDM4E (0.44) | KDM4EHTTATMAHRALDH1A1 | |
| SCHEMBL863879 | 0.85 | HDAC3 (0.45) | KDM4EHTTATMAHRHTR2C | |
| SCHEMBL863663 | 0.83 | HTR2C (0.46) | HTTAHRMAPTLMNABLM | |
| SCHEMBL31515327 | 0.82 | HDAC3 (0.43) | CA1CA2CA7CA9DRD2 | |
| Hydrochloric Acid SCHEMBL10502567 | 0.82 | HTR2C (0.44) | HTTAHRMAPTLMNABLM | |
| SCHEMBL2090589 | 0.81 | HRH3 (0.38) | AHRDRD2 | |
| SCHEMBL31515224 | 0.81 | HDAC3 (0.38) | KDM4EHTTATMCA1CA2 | |
| Hydrochloric Acid SCHEMBL10502741 | 0.81 | HDAC3 (0.44) | KDM4EHTTATMHTR2C | |
| Hydrochloric Acid SCHEMBL10502742 | 0.81 | HDAC3 (0.44) | KDM4EHTTATMHTR2C | |
| SCHEMBL13910958 | 0.79 | KDM4E (0.63) | KDM4EHTTATMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4623657-A | HYPOTENSIVE, ANTICONVULSANT, ANALGESIC, ANTIDEPRESSANT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-11-18 | — | — | US | claimed |
| EP-0217135-B1 | Spiro[benzofuran-2(3H), 1'cycloheptane]s, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-10-25 | — | — | EP | disclosed |
| EP-0217135-A1 | Spiro[benzofuran-2(3H), 1'cycloheptane]s, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1987-04-08 | — | — | EP | disclosed |
| US-4623657-A | HYPOTENSIVE, ANTICONVULSANT, ANALGESIC, ANTIDEPRESSANT | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1986-11-18 | — | — | US | disclosed |