Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.63 |
| ▸ | PPARD | Q03181 | 4/20 | 0.63 |
| ▸ | PPARA | Q07869 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | F7 | P08709 | 4/20 | 0.63 |
| ▸ | F3 | P13726 | 4/20 | 0.63 |
| ▸ | TERT | O14746 | 3/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.63 |
| ▸ | BLM | P54132 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | FABP4 | P15090 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | RECQL | P46063 | 2/20 | 0.63 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.63 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10608663 | 1.00 | PPARG (0.63) | PPARGPPARDPPARAMAPTF7 | |
| Oleic Acid SCHEMBL1359918 | 0.92 | PPARG (0.74) | PPARGPPARDPPARAMAPTF7 | |
| Linoleic Acid SCHEMBL22472228 | 0.89 | PPARG (0.79) | PPARGPPARDPPARAMAPTF7 | |
| SCHEMBL25307961 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL1116082 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL8042209 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL1116115 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL2142069 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL2832841 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 | |
| SCHEMBL14335482 | 0.88 | TSHR (0.60) | PPARGPPARDPPARAPTPN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0156100-B1 | 3-SUBSTITUTED HYDROXYPENTANEDIOIC ACIDS, -HEMIESTERS OR -ANHYDRIDES | G.D. Searle & Co. (US) | 1989-12-27 | — | — | EP | disclosed |
| US-4554359-A | 3-Substituted pentanedioic acids and derivatives thereof | G. D. SEARLE & CO. (US) | 1985-11-19 | — | — | US | disclosed |
| EP-0156100-A2 | 3-Substituted hydroxypentanedioic acids, -hemiesters or -anhydrides | G.D. Searle & Co. (US) | 1985-10-02 | — | — | EP | disclosed |