SCHEMBL10614366

SCHEMBL10614366

COC(=O)C1=C(C)NC(CCC(SC(C)=O)c2ccccc2)=C(C(=O)OC)C1c1ccccc1C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 3/20 0.56
CACNA1F O60840 1/20 0.56
CACNA1D Q01668 1/20 0.56
CACNA1S Q13698 1/20 0.56
CYP1A2 P05177 3/20 0.50
CYP3A4 P08684 3/20 0.50
ADORA3 P0DMS8 3/20 0.50
MAPT P10636 3/20 0.50
CYP2C9 P11712 3/20 0.50
CYP2C19 P33261 3/20 0.50
TSHR P16473 2/20 0.50
NFKB1 P19838 2/20 0.50
MEN1 O00255 1/20 0.50
CYP2D6 P10635 1/20 0.50
KMT2A Q03164 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10614380 0.86 CACNA1F (0.44) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL7427151 0.84 CACNA1F (0.56) CACNA1CCACNA1FCACNA1DCACNA1SADORA3
SCHEMBL9809456 0.82 CACNA1F (0.61) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9809525 0.82 CACNA1F (0.60) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9809478 0.80 CACNA1F (0.57) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7436390 0.78 CACNA1F (0.56) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL9809562 0.78 CACNA1F (0.55) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7431449 0.77 CACNA1C (0.78) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2
SCHEMBL9809485 0.77 CACNA1F (0.53) CACNA1CCACNA1FCACNA1DCACNA1S
SCHEMBL7383158 0.76 CACNA1C (0.61) CACNA1CCACNA1FCACNA1DCACNA1SCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1988005043-A1 NEW ARALKYL-1,4-DIHYDROPYRIDINES, A METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BOEHRINGER BIOCHEMIA ROBIN S.P.A. (IT) 1988-07-14 WO disclosed