SCHEMBL10619481

SCHEMBL10619481

Cc1ccc(-n2ncc(C#N)c2N)c(Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.50
KDM4E B2RXH2 3/20 0.48
MEN1 O00255 2/20 0.48
ALDH1A1 P00352 4/20 0.46
NPSR1 Q6W5P4 2/20 0.46
XDH P47989 2/20 0.44
MAPT P10636 2/20 0.40
RXRA P19793 1/20 0.38
RXRB P28702 1/20 0.38
RXRG P48443 1/20 0.38
HPGD P15428 3/20 0.37
RXFP1 Q9HBX9 2/20 0.36
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
GLA P06280 1/20 0.35
F2 P00734 1/20 0.35
HTT P42858 1/20 0.34
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10986422 0.90 KMT2A (0.49) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10987859 0.90 KMT2A (0.49) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10988076 0.89 KMT2A (0.48) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL9453060 0.85 KMT2A (0.50) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10985992 0.84 KMT2A (0.49) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10986784 0.83 KMT2A (0.48) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10988284 0.82 KMT2A (0.47) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10619039 0.82 KMT2A (0.45) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL8043513 0.82 KMT2A (0.52) KMT2AKDM4EMEN1ALDH1A1NPSR1
SCHEMBL10967579 0.82 KMT2A (0.52) KMT2AKDM4EMEN1ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4496390-A WEED-CONTRTOLLING HERBICIDES MAY & BAKER LIMITED (GB) 1985-01-29 US claimed
EP-0083613-B1 N-PHENYLPYRAZOLE DERIVATIVES USEFUL AS HERBICIDES MAY & BAKER LIMITED (GB) 1988-06-01 EP disclosed
EP-0034945-B1 N-PHENYLPYRAZOLE DERIVATIVES MAY & BAKER LIMITED (GB) 1985-08-07 EP disclosed
US-4505740-A Herbicidal 5-amino-4-cyano-1-phenyl-pyrazoles MAY & BAKER LIMITED (GB) 1985-03-19 US disclosed
US-4496390-A WEED-CONTRTOLLING HERBICIDES MAY & BAKER LIMITED (GB) 1985-01-29 US disclosed
US-4459150-A 5-Acylamino-4-cyano-1-phenylpyrazole derivatives and use as herbicides MAY & BAKER LIMITED (GB) 1984-07-10 US disclosed
EP-0083613-A1 N-PHENYLPYRAZOLE DERIVATIVES USEFUL AS HERBICIDES. MAY & BAKER LTD (GB) 1983-07-20 EP disclosed
WO-1983000332-A1 N-PHENYLPYRAZOLE DERIVATIVES USEFUL AS HERBICIDES MAY & BAKER LTD (GB) 1983-02-03 WO disclosed
EP-0034945-A2 N-phenylpyrazole derivatives MAY & BAKER LIMITED (GB) 1981-09-02 EP disclosed