Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 16/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10618227 | 0.99 | KDM4E (0.64) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10765293 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10760066 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10621089 | 0.86 | KDM4E (0.71) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10619067 | 0.84 | KDM4E (0.69) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10618288 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10619070 | 0.83 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10618267 | 0.82 | KDM4E (0.76) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10616554 | 0.82 | KDM4E (0.66) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 | |
| SCHEMBL10725545 | 0.80 | PDE3B (0.65) | KDM4EALDH1A1CYP1A2CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0084250-B1 | 6-(SUBSTITUTED PHENYL)-4,5-DIHYDRO-3-(2H)-PYRIDAZINONE COMPOUNDS AND PROCESSES FOR THEIR PREPARATION | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1988-06-22 | — | — | EP | disclosed |
| US-4523011-A | PLATELET AGGREGATION INHIBITOR, BLOOD PRESSURE DEPRESSANT | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1985-06-11 | — | — | US | disclosed |
| US-4521415-A | ANTICOAGULANT, HYPOTENSIVE AGENT | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1985-06-04 | — | — | US | disclosed |
| EP-0084250-A2 | 6-(Substituted phenyl)-4,5-dihydro-3-(2H)-pyridazinone compounds and processes for their preparation | MITSUI TOATSU KAGAKU KABUSHIKI KAISHA (JP) | 1983-07-27 | — | — | EP | disclosed |