Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.74 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.74 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10631798 | 1.00 | HMGCR (0.74) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10631793 | 1.00 | HMGCR (0.74) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628292 | 0.92 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628298 | 0.92 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10628294 | 0.92 | HMGCR (0.77) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL13909416 | 0.90 | HMGCR (0.75) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL13909418 | 0.90 | HMGCR (0.75) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10799442 | 0.89 | HMGCR (0.65) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10799453 | 0.89 | HMGCR (0.65) | HMGCRABCB1ABCC2SLCO1B1 | |
| SCHEMBL10799445 | 0.89 | HMGCR (0.65) | HMGCRABCB1ABCC2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4775681-A | Method of treating fungal infections with trans-6-[2-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones | WARNER-LAMBERT COMPANY (US) | 1988-10-04 | — | — | US | disclosed |
| US-4647576-A | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1987-03-03 | — | — | US | disclosed |
| EP-0179559-A2 | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1986-04-30 | — | — | EP | disclosed |