Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10960054 | 0.87 | GBA2 (0.35) | GAACHRM1GBA2TP53TDP1 | |
| SCHEMBL22032095 | 0.81 | TP53 (0.36) | GAACHRM1TP53TDP1ALDH1A1 | |
| SCHEMBL30000807 | 0.79 | CHRM2 (0.51) | CHRM1HSD11B1 | |
| SCHEMBL21608178 | 0.79 | CHRM2 (0.51) | CHRM1HSD11B1 | |
| SCHEMBL30411550 | 0.79 | CHRM2 (0.51) | CHRM1HSD11B1 | |
| SCHEMBL30412344 | 0.79 | CHRM2 (0.51) | CHRM1HSD11B1 | |
| SCHEMBL30000570 | 0.79 | CHRM2 (0.51) | CHRM1HSD11B1 | |
| SCHEMBL17039078 | 0.78 | GAA (0.38) | GAACHRM1ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL22032112 | 0.77 | TP53 (0.35) | GAACHRM1TP53TDP1ALDH1A1 | |
| SCHEMBL21598126 | 0.75 | TDP1 (0.36) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115933-B1 | AMIDE DERIVATIVES OF AZABICYCLOALKANES | BEECHAM GROUP PLC (GB) | 1988-05-25 | — | — | EP | disclosed |
| US-4533498-A | Compounds | BEECHAM GROUP P.L.C. (GB) | 1985-08-06 | — | — | US | disclosed |
| EP-0115933-A2 | Amide derivatives of azabicycloalkanes | BEECHAM GROUP PLC (GB) | 1984-08-15 | — | — | EP | disclosed |