Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.36 |
| ▸ | PPARG | P37231 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 3/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643048 | 0.82 | GPBAR1 (0.39) | PPARAGPBAR1PPARGPPARDMEN1 | |
| SCHEMBL10642613 | 0.79 | KDM4E (0.43) | TYMPPPARAGPBAR1PPARGPPARD | |
| SCHEMBL10647442 | 0.76 | CA1 (0.37) | PPARAGPBAR1PPARGPPARDTHRB | |
| SCHEMBL10643636 | 0.75 | GPBAR1 (0.34) | PPARAGPBAR1PPARGPPARDTHRB | |
| SCHEMBL10656039 | 0.74 | PPARA (0.42) | PPARAPPARGPPARDFFAR4 | |
| SCHEMBL10659796 | 0.71 | PPARD (0.48) | PPARAPPARGPPARDMAPTFFAR4 | |
| SCHEMBL11557734 | 0.71 | HTR2A (0.39) | GPBAR1MAPT | |
| SCHEMBL11557738 | 0.71 | ESR1 (0.44) | GPBAR1MEN1KMT2A | |
| SCHEMBL10644625 | 0.70 | POLB (0.41) | PPARAGPBAR1PPARGPPARDMEN1 | |
| SCHEMBL10647120 | 0.68 | PTGDR2 (0.36) | GPBAR1MEN1KMT2AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147691-B1 | ANTIHYPERTENSIVE 3-ARYL-1,2-BENZISOXAZOLSULFONYL AND-SULFINYL-ALKANOIC ACIDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4602028-A | Antihypertensive 3-aryl-1,2-benzisoxazol-sulfonyl and sulfinylalkanoic acids | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-07-22 | — | — | US | disclosed |
| EP-0147691-A1 | Antihypertensive 3-aryl-1,2-benzisoxazolsulfonyl and-sulfinyl-alkanoic acids, a process for their preparation and their use for the preparation of medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-07-10 | — | — | EP | disclosed |