Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 5/20 | 0.77 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10646001 | 0.98 | CCR3 (0.74) | CCR3EPHX1GAAMCHR1CHRM4 | |
| SCHEMBL10644928 | 0.90 | EPHX1 (0.65) | CCR3EPHX1GAASIGMAR1NPC1 | |
| Hydrochloric Acid SCHEMBL10644494 | 0.89 | EPHX1 (0.63) | CCR3EPHX1GAASIGMAR1NPC1 | |
| SCHEMBL10642292 | 0.89 | EPHX1 (0.66) | CCR3EPHX1GAAALDH1A1CYP1A2 | |
| SCHEMBL10642211 | 0.88 | EPHX1 (0.62) | CCR3EPHX1GAANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10757369 | 0.88 | EPHX1 (0.65) | CCR3EPHX1GAAALDH1A1CYP1A2 | |
| SCHEMBL6329152 | 0.87 | CCR3 (1.00) | CCR3 | |
| Hydrochloric Acid SCHEMBL10644696 | 0.87 | EPHX1 (0.61) | CCR3EPHX1GAANPC1RAB9A | |
| SCHEMBL22315365 | 0.80 | EPHX1 (0.76) | CCR3EPHX1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL491868 | 0.79 | EPHX1 (0.79) | CCR3EPHX1GAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129207-B1 | SUBSTITUTED PHENYLALKYL(PIPERAZINYL OR HOMOPIPERAZINYL)-PROPYL-(UREAS OR THIOUREAS) | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1988-03-16 | — | — | EP | claimed |
| US-4579947-A | Substituted phenylalkylpiperazinylpropyl (ureas or thioureas) useful for treatment of immunological, inflammatory and allergic disorder | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1986-04-01 | — | — | US | claimed |
| EP-0129207-A2 | Substituted phenylalkyl(piperazinyl or homopiperazinyl)-propyl-(ureas or thioureas) | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0129207-B1 | SUBSTITUTED PHENYLALKYL(PIPERAZINYL OR HOMOPIPERAZINYL)-PROPYL-(UREAS OR THIOUREAS) | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1988-03-16 | — | — | EP | disclosed |
| US-4661481-A | Substituted phenylalkylhomopiperazinylpropyl(ureas or thioureas) useful for treatment of immulogical, inflammatory and allergic disorders | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC (US) | 1987-04-28 | — | — | US | disclosed |
| US-4579947-A | Substituted phenylalkylpiperazinylpropyl (ureas or thioureas) useful for treatment of immunological, inflammatory and allergic disorder | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 1986-04-01 | — | — | US | disclosed |