Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 16/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 14/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.63 |
| ▸ | PDE4A | P27815 | 2/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.63 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10725276 | 0.92 | PDE3B (0.54) | PDE3APDE3BPDE4BPDE4APDE4C | |
| Fumaric Acid SCHEMBL10725290 | 0.92 | PDE3B (0.54) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10724940 | 0.85 | PDE3B (0.65) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL11061204 | 0.80 | PDE3B (0.68) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL11061207 | 0.80 | PDE3B (0.68) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10651787 | 0.79 | PDE3B (0.63) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10646441 | 0.79 | PBRM1 (0.49) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10730489 | 0.79 | PDE3B (0.41) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10647873 | 0.78 | PBRM1 (0.48) | PDE3APDE3BPDE4BPDE4APDE4C | |
| SCHEMBL10363627 | 0.78 | PDE3B (0.42) | PDE3APDE3BPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | claimed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | claimed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | claimed |
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| US-4746660-A | Process for reducing reflex tachycardia in the treatment of hypertension employing a combination of a diazacyclopentene derivative and a pyridazinone derivative | A. Natternabb & CIE GmbH (DE) | 1988-05-24 | — | — | US | disclosed |
| US-4661487-A | CARDIOVASCULAR DISORDERS | A. NATTERMANN & CIE GMBH (DE) | 1987-04-28 | — | — | US | disclosed |
| EP-0112987-B1 | IMIDAZOLYLALKYLTHIENYL-TETRAHYDROPYRIDAZINES AND PROCESS FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1987-04-01 | — | — | EP | disclosed |
| US-4643998-A | Imidazolylalkylthienyl tetrahydropyridazines and processes for their use | A. NATTERMAN & CIE GMBH (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0156163-A1 | Pharmaceutical product for the treatment of hypertension and thromboembolic diseases | A. Nattermann & Cie. GmbH (DE) | 1985-10-02 | — | — | EP | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |
| EP-0122419-A2 | Substituted 3-mercaptopyridazines, their 3-alkylthio derivatives and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-10-24 | — | — | EP | disclosed |
| EP-0112987-A1 | Imidazolylalkylthienyl-tetrahydropyridazines and process for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-07-11 | — | — | EP | disclosed |