Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648178 | 0.93 | PDE3B (0.44) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10645518 | 0.92 | PDE3B (0.43) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10977421 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10926514 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10922733 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10922175 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10926117 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10924625 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10926374 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 | |
| SCHEMBL10648292 | 0.91 | PDE3B (0.42) | PDE3BPDE3ALMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4504479-A | 6-{5-[ω-(1-Imidazolyl)-alkyl]-thien-2-yl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof and a process for the treatment of inflammatory atherosclerotic and thrombo-embolic, illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-12 | — | — | US | claimed |
| EP-0128502-B1 | SUBSTITUTED 6-(THIEN-2-YL)-3(2H)-PYRIDAZINONES AND PROCESSES FOR THEIR PREPARATION | A. Nattermann & Cie. GmbH (DE) | 1988-08-31 | — | — | EP | disclosed |
| EP-0071059-B1 | 6-(5-(OMEGA-(1-IMIDAZOLYL)-ALKYL)-THIEN-2-YL)-3-OXO-2,3,4,5-TETRAHYDROPYRIDAZINES AND THEIR ACID-ADDITION SALTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | A. Nattermann & Cie. GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| US-4504479-A | 6-{5-[ω-(1-Imidazolyl)-alkyl]-thien-2-yl}-3-oxo-2,3,4,5-tetrahydro-pyridazines and acid addition salts thereof and a process for the treatment of inflammatory atherosclerotic and thrombo-embolic, illnesses in humans | A. NATTERMANN & CIE GMBH (DE) | 1985-03-12 | — | — | US | disclosed |
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |
| EP-0071059-A2 | 6-(5-(Omega-(1-imidazolyl)-alkyl)-thien-2-yl)-3-oxo-2,3,4,5-tetrahydropyridazines and their acid-addition salts, process for their preparation and pharmaceutical compounds containing them | A. Nattermann & Cie. GmbH (DE) | 1983-02-09 | — | — | EP | disclosed |