Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 6/20 | 0.57 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212651 | 0.78 | HDAC1 (0.57) | HDAC1HDAC2MAPK1HDAC3NCOR2 | |
| SCHEMBL1064676 | 0.77 | HDAC1 (0.71) | HDAC1PTGS2HDAC2NPC1RAB9A | |
| SCHEMBL2108665 | 0.76 | HDAC1 (1.00) | HDAC1HDAC2NPC1RAB9AHDAC3 | |
| SCHEMBL211197 | 0.76 | HDAC1 (0.59) | HDAC1PTGS2HDAC2NPC1RAB9A | |
| SCHEMBL211754 | 0.76 | HDAC1 (0.73) | HDAC1HDAC2NPC1RAB9AMAPK1 | |
| SCHEMBL27900969 | 0.76 | HDAC1 (0.64) | HDAC1HDAC2MAPK1HDAC3NCOR2 | |
| SCHEMBL8401704 | 0.74 | HDAC1 (0.89) | HDAC1HDAC2NPC1RAB9AMAPK1 | |
| SCHEMBL27406949 | 0.73 | HDAC1 (0.69) | HDAC1HDAC2MAPK1HDAC3NCOR2 | |
| SCHEMBL1064065 | 0.73 | HDAC1 (0.60) | HDAC1HDAC2MAPK1HDAC3NCOR2 | |
| SCHEMBL28402288 | 0.73 | HDAC1 (1.00) | HDAC1HDAC2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-20060058298-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2006-03-16 | — | — | US | disclosed |
| US-20050288282-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288282-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885PTGS2 2854/4885HDAC2 5/4885 |
| US-20060058298-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885PTGS2 2854/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.