Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.70 |
| ▸ | BACE1 | P56817 | 2/20 | 0.67 |
| ▸ | REN | P00797 | 1/20 | 0.63 |
| ▸ | CTSD | P07339 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307529 | 0.92 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL10646574 | 0.90 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL10653875 | 0.88 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL10647105 | 0.88 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DBACE1 | |
| SCHEMBL10649452 | 0.87 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10646753 | 0.87 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10649134 | 0.86 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10651610 | 0.85 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10651792 | 0.83 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7307591 | 0.83 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |