Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.81 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.81 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.81 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.81 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063455 | 1.00 | HDAC1 (0.81) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL23746024 | 0.90 | HDAC1 (0.90) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL8348463 | 0.89 | HDAC1 (0.83) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL1064825 | 0.87 | HDAC1 (0.76) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL1058479 | 0.87 | HDAC1 (0.75) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL1064283 | 0.86 | HDAC1 (0.79) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL28188848 | 0.85 | MEN1 (0.77) | HDAC1HDAC2HDAC3NCOR2HDAC4 | |
| SCHEMBL8352492 | 0.85 | HDAC1 (0.58) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL13389551 | 0.85 | MEN1 (0.60) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL210691 | 0.85 | HDAC1 (0.69) | HDAC1HDAC2HDAC3NCOR2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3336078-A1 | BENZAMIDE DERIVATIVE AS HISTONE DEACETYLASE INHIBITOR WITH POTENT DIFFERENTIATION AND ANTI-PROLIFERATION ACTIVITY | Shenzhen Chipscreen Biosciences Ltd. (CN) | 2018-06-20 | — | — | EP | disclosed |
| EP-2860174-B1 | Benzamide Derivative as Histone Deacetylase Inhibitor with Potent Differentiation and Anti-Proliferation Activity | SHENZHEN CHIPSCREEN BIOSCIENCES LTD (CN) | 2017-11-29 | — | — | EP | disclosed |
| EP-2860174-A2 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation acivity | Shenzhen Chipscreen Biosciences Ltd. (CN) | 2015-04-15 | — | — | EP | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |
| US-7550490-B2 | Benzamide derivatives as histone deacetylase inhibitors with potent differentiation and anti-proliferation activity | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2009-06-23 | — | — | US | disclosed |
| US-20080039509-A1 | Histone Deacetylase Inhibitors or Novel Benzamine Derivatives with Potent Differentiation and Anti-Proliferation Activity | SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. | 2008-02-14 | — | — | US | disclosed |
| EP-1592665-A4 | HISTONE DEACETYLASE INHIBITORS OF NOVEL BENZAMIDE DERIVATIVES WITH POTENT DIFFERENTIATION AND ANTI-PROLIFERATION ACTIVITY | SHENZHEN CHIPSCREEN BIOSCIENCE (CN) | 2007-07-18 | — | — | EP | disclosed |
| US-7244751-B2 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2007-07-17 | — | — | US | disclosed |
| US-20060058298-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2006-03-16 | — | — | US | disclosed |
| US-20050288282-A1 | Inhibitors of histone deacetylase | METHYLGENE, INC. | 2005-12-29 | — | — | US | disclosed |
| EP-1592665-A2 | HISTONE DEACETYLASE INHIBITORS OF NOVEL BENZAMIDE DERIVATIVES WITH POTENT DIFFERENTIATION AND ANTI-PROLIFERATION ACTIVITY | Shenzhen Chipscreen Biosciences Ltd. (CN) | 2005-11-09 | — | — | EP | disclosed |
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |
| US-20040224991-A1 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (CN) | 2004-11-11 | — | — | US | disclosed |
| WO-2004071400-A2 | HISTONE DEACETYLASE INHIBITORS OF NOVEL BENZAMIDE DERIVATIVES WITH POTENT DIFFERENTIATION AND ANTI-PROLIFERATION ACTIVITY | SHENZHEN CHIPSCREEN BIOSCIENCES LTD. (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288282-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC2 5/4885HDAC3 3/4885 |
| US-20040224991-A1 | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity | HDAC1, HDAC5, HDAC11 | HDAC1 1/4885HDAC2 7/4885HDAC3 12/4885 |
| US-20080039509-A1 | Histone Deacetylase Inhibitors or Novel Benzamine Derivatives with Potent Differentiation and Anti-Proliferation Activity | HDAC5, HDAC1, HDAC7 | HDAC1 2/4885HDAC2 8/4885HDAC3 12/4885 |
| US-20060058298-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC2 5/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.