Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10648924 | 1.00 | STAT3 (0.54) | STAT3LMNAKMT2AHPGDPKM | |
| SCHEMBL29302355 | 0.91 | EGFR (0.51) | STAT3LMNAKMT2AHPGDPKM | |
| SCHEMBL29137054 | 0.91 | EGFR (0.51) | STAT3LMNAKMT2AHPGDPKM | |
| SCHEMBL1177984 | 0.85 | STAT3 (0.60) | STAT3LMNAKMT2AHPGDPKM | |
| SCHEMBL6986690 | 0.85 | STAT3 (0.60) | STAT3LMNAKMT2AHPGDPKM | |
| SCHEMBL4688056 | 0.84 | STAT3 (0.74) | STAT3LMNAKMT2AHPGDMEN1 | |
| SCHEMBL12226830 | 0.84 | STAT3 (0.74) | STAT3LMNAKMT2AHPGDMEN1 | |
| SCHEMBL4688054 | 0.84 | STAT3 (0.74) | STAT3LMNAKMT2AHPGDMEN1 | |
| SCHEMBL10783189 | 0.81 | CA12 (0.59) | STAT3LMNAKMT2AHPGDMEN1 | |
| SCHEMBL28855669 | 0.80 | EGFR (0.45) | STAT3LMNAKMT2AHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153006-B1 | BENZOTRICYCLIC NITROGEN-CONTAINING DIONES AND A PROCESS FOR THE PRODUCTION THEREOF | WARNER-LAMBERT COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |
| US-4677112-A | 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators | WARNER-LAMBERT COMPANY (US) | 1987-06-30 | — | — | US | disclosed |
| US-4582909-A | Benzobicyclic lactam acids and derivatives as cognition activators | WARNER-LAMBERT COMPANY (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0153006-A1 | Benzotricyclic nitrogen-containing diones and a process for the production thereof | WARNER-LAMBERT COMPANY (US) | 1985-08-28 | — | — | EP | disclosed |
| EP-0151539-A2 | Benzobicyclic lactam acids, their derivatives, an intermediate in the preparation thereof and processes for the production thereof | WARNER-LAMBERT COMPANY (US) | 1985-08-14 | — | — | EP | disclosed |
| US-4530929-A | Tricyclic containing an imide group | WARNER-LAMBERT COMPANY (US) | 1985-07-23 | — | — | US | disclosed |