Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313605 | 0.88 | PDE4A (0.40) | KMT2AMEN1PDE4APDE4BPDE4C | |
| SCHEMBL10649438 | 0.85 | PDE4A (0.32) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10649789 | 0.85 | NPC1 (0.38) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL10649609 | 0.80 | NPC1 (0.38) | NPC1RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL10648123 | 0.78 | KMT2A (0.39) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL7308357 | 0.74 | PDE3B (0.36) | NPC1RAB9AKMT2AMEN1HPGD | |
| SCHEMBL7321069 | 0.74 | PDE4A (0.43) | KMT2AMEN1L3MBTL1PDE4APDE4B | |
| SCHEMBL7311174 | 0.73 | PDE4A (0.40) | NPC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10665307 | 0.72 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7306426 | 0.71 | PDE4A (0.40) | KMT2AMEN1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254327-A2 | N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl) oxyalkylamides and related compounds | SYNTEX (U.S.A.) INC. (US) | 1988-01-27 | — | — | EP | disclosed |