Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10653778 | 0.98 | KMT2A (0.32) | KMT2A | |
| Iodide SCHEMBL10970392 | 0.85 | KMT2A (0.31) | KMT2A | |
| SCHEMBL13739781 | 0.77 | CYP3A4 (0.32) | KMT2A | |
| SCHEMBL10849880 | 0.75 | PARP1 (0.33) | KMT2A | |
| Iodide SCHEMBL10648494 | 0.74 | KMT2A (0.48) | KMT2A | |
| SCHEMBL10648921 | 0.71 | — | — | |
| SCHEMBL8505979 | 0.69 | — | — | |
| SCHEMBL8660652 | 0.64 | — | — | |
| SCHEMBL11084110 | 0.61 | — | — | |
| SCHEMBL14423078 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132914-B1 | IMIDAZOLINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-06-08 | — | — | EP | disclosed |
| US-4567176-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-01-28 | — | — | US | disclosed |
| EP-0132914-A2 | Imidazolinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-02-13 | — | — | EP | disclosed |
| WO-1984004304-A1 | AMINOIMIDAZOLONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE FRENCH LAB (GB) | 1984-11-08 | — | — | WO | disclosed |