Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16022549 | 1.00 | MAPT (0.64) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL19290957 | 1.00 | MAPT (0.64) | MAPTPDK1PDK2PDK3PDK4 | |
| Hydrochloric Acid SCHEMBL8869283 | 0.98 | MAPT (0.62) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL30843766 | 0.85 | MAPT (0.54) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL29250499 | 0.85 | MAPT (0.54) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL24106805 | 0.85 | MAPT (0.54) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL28531602 | 0.85 | MAPT (0.54) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL28510594 | 0.85 | MAPT (0.54) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17426061 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 | |
| SCHEMBL17069524 | 0.84 | MAPT (0.70) | MAPTPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132845-B1 | NOVEL 1,8-NAPHTHYRIDINE DERIVATIVES, AND PROCESS FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1988-04-13 | — | — | EP | disclosed |
| US-4649144-A | Antibacterial 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| EP-0132845-A2 | Novel 1,8-Naphthyridine derivatives, and process for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |
| US-4210660-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, ESPECIALLY ANTIPSYCOTICS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1980-07-01 | — | — | US | disclosed |