Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | DRD1 | P21728 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654545 | 0.89 | KCNH2 (0.44) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10651317 | 0.89 | KCNH2 (0.44) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL38660198 | 0.86 | CHRM2 (0.57) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10651082 | 0.84 | KCNH2 (0.43) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10654586 | 0.84 | HRH1 (0.43) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL16491451 | 0.83 | CYP2D6 (0.57) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL225860 | 0.82 | CYP2D6 (0.52) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL29390583 | 0.82 | CYP2D6 (0.52) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10652605 | 0.81 | GBA1 (0.66) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 | |
| SCHEMBL10752090 | 0.81 | GBA1 (0.51) | CHRM2ADRA2ADRD1SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113572-B1 | PYRIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-02-03 | — | — | EP | disclosed |
| US-4547506-A | 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H1 -antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-10-15 | — | — | US | disclosed |
| EP-0113572-A2 | Pyridine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-07-18 | — | — | EP | disclosed |