Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319539 | 0.75 | HDAC8 (0.44) | DBHMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL28386141 | 0.74 | TAAR1 (0.34) | KDM4E | |
| SCHEMBL1563931 | 0.73 | CNR2 (0.49) | DBHCA12CA1CA2CA9 | |
| SCHEMBL14602502 | 0.73 | HDAC8 (0.49) | DBHMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3318333 | 0.71 | SLC6A4 (0.45) | MAPTCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL8077068 | 0.69 | MAPT (0.62) | CA12CA1CA2CA9CNR2 | |
| SCHEMBL1606703 | 0.68 | CA12 (0.67) | CA12CA1CA2CA9CNR2 | |
| SCHEMBL4961233 | 0.68 | KDM4E (0.63) | CA12CA1CA2CA9CNR2 | |
| SCHEMBL10654906 | 0.68 | TAAR1 (0.52) | DBHCA12CA1CA2CA9 | |
| SCHEMBL3317011 | 0.68 | HDAC8 (0.47) | MAPTSMN1; SMN2ALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270596-A1 | A STEREOCONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S)- AND (R)-2-AMINOMETHYLPYRROLIDINES AND INTERMEDIATES THERETO | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1988-06-15 | — | — | EP | disclosed |
| WO-1987007271-A1 | A STEREOCONSERVATIVE SYNTHESIS OF 1-SUBSTITUTED (S)- AND (R)-2-AMINOMETHYLPYRROLIDINES AND INTERMEDIATES THERETO | Astra Läkemedel Aktiebolag (SE) | 1987-12-03 | — | — | WO | disclosed |