Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PMM2 | O15305 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379090 | 0.85 | MAPT (0.46) | PDE4BPDE4DPMM2MPIPHOSPHO1 | |
| SCHEMBL9629153 | 0.83 | FEN1 (0.50) | PDE4BPDE4DALDH1A1MAPT | |
| SCHEMBL10376581 | 0.82 | KAT2B (0.49) | PDE4BPDE4DPMM2MPIPOLB | |
| SCHEMBL10377346 | 0.81 | PDE4B (0.42) | PDE4BPDE4DALOX5MAPTKMT2A | |
| SCHEMBL10660694 | 0.81 | PDE4B (0.42) | PDE4BPDE4DPMM2MPIPHOSPHO1 | |
| SCHEMBL10660620 | 0.80 | TNF (0.38) | PDE4BPDE4DKMT2A | |
| SCHEMBL10378837 | 0.80 | MAPT (0.38) | PDE4BPDE4DTP53CYP1A2ALDH1A1 | |
| SCHEMBL10377552 | 0.80 | KAT2B (0.44) | PDE4BPDE4DTP53ALDH1A1MAPT | |
| SCHEMBL10379093 | 0.80 | KAT2B (0.47) | PDE4BPDE4DTP53POLBCYP1A2 | |
| SCHEMBL10659673 | 0.80 | PDE4A (0.36) | PDE4BPDE4DALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |