Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.32 |
| ▸ | BRD4 | O60885 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630898 | 0.85 | HPGD (0.49) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL10654511 | 0.85 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL9629927 | 0.83 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL9629788 | 0.83 | KAT2B (0.45) | PDE4BPDE4DHPGDMAPTKDM4E | |
| SCHEMBL10661052 | 0.82 | PDE4A (0.36) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL10739188 | 0.82 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL10654514 | 0.82 | PDE4B (0.42) | PDE4BPDE4DHPGDCYP1A2MAPT | |
| SCHEMBL10659535 | 0.82 | TNF (0.39) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL9629709 | 0.81 | HPGD (0.40) | PDE4APDE4BPDE4CPDE4DHPGD | |
| SCHEMBL9630048 | 0.80 | KAT2B (0.42) | PDE4BPDE4DHPGDCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |