Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 7/20 | 0.53 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.53 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.53 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11681591 | 0.92 | MAPT (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL31191654 | 0.92 | MAPT (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL3443991 | 0.90 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL3443984 | 0.90 | CACNA1F (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL14977478 | 0.88 | MAPT (0.49) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL14977476 | 0.88 | MAPT (0.49) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL3443986 | 0.86 | CYP1A2 (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL16189736 | 0.86 | TSHR (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL30873727 | 0.86 | CYP1A2 (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL7482293 | 0.85 | CACNA1F (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206480-A | Purification method of 1, 4-dihydro-2, 6-dimethyl-4- (3-nitrophenyl) pyridine-3, 5-dicarboxylic acid monomethyl ester | 河北一品生物医药有限公司 | 2024-06-18 | — | — | CN | claimed |
| CN-118930479-A | Preparation method of benidipine hydrochloride | 重庆煜洋药业有限公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118930479-A | Preparation method of benidipine hydrochloride | 重庆煜洋药业有限公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-118206480-A | Purification method of 1, 4-dihydro-2, 6-dimethyl-4- (3-nitrophenyl) pyridine-3, 5-dicarboxylic acid monomethyl ester | 河北一品生物医药有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115322118-B | Preparation method of benidipine hydrochloride intermediate | 重庆华邦制药有限公司 | 2024-04-30 | — | — | CN | disclosed |
| CN-1015460-B | Process for preparing derivatives of asymmetric esters of 1, 4-dihydropyridine-3, 5-dicarboxylic acid | SORI SOC RECH IND (FR) | 1992-02-12 | — | — | CN | disclosed |
| EP-0245680-A3 | A PROCESS FOR THE PREPARATION OF 2-(N-BENZYL-N-METHYLAMINO)-ETHYL-METHYL-1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINE DICARBOXYLATE HYDROCHLORIDE | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1988-04-20 | — | — | EP | disclosed |
| EP-0245680-A2 | A process for the preparation of 2-(N-benzyl-N-methylamino)-ethyl-methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine dicarboxylate hydrochloride | ISTITUTO LUSO FARMACO D'ITALIA S.p.A. (IT) | 1987-11-19 | — | — | EP | disclosed |
| CN-87102452-A | 1, the derivative of the asymmetric ester of 4-dihydropyridine-3,5-dicarboxylic acid | — | 1987-10-14 | — | — | CN | disclosed |