SCHEMBL10657410

SCHEMBL10657410

CCC(Oc1ccc2c(-c3ccccc3Cl)noc2c1Cl)C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.41
TP53 P04637 2/20 0.41
PPARD Q03181 5/20 0.40
NR1H4 Q96RI1 3/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
HSD17B10 Q99714 1/20 0.40
PPARG P37231 3/20 0.39
PPARA Q07869 3/20 0.39
LMNA P02545 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10665132 0.91 PPARA (0.40) PPARDPPARGPPARASMN1; SMN2
SCHEMBL10661841 0.90 MAPT (0.41) MAPTPPARDPPARGPPARA
SCHEMBL10658961 0.89 PPARA (0.48) PPARDPPARGPPARA
SCHEMBL10659324 0.89 PPARA (0.52) PPARDPPARGPPARALMNASMN1; SMN2
SCHEMBL10658761 0.87 PPARA (0.39) PPARDNR1H4PPARGPPARASMN1; SMN2
SCHEMBL10659166 0.84 PPARA (0.37) MAPTPPARDALDH1A1POLBHPGD
SCHEMBL10656039 0.84 PPARA (0.42) PPARDPPARGPPARA
SCHEMBL10658173 0.83 PPARA (0.38) PPARDPOLBPPARGPPARALMNA
SCHEMBL10659584 0.83 PPARA (0.41) MAPTPPARDPPARGPPARASMN1; SMN2
SCHEMBL10656055 0.82 FABP3 (0.40) MAPTTP53PPARDALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4728662-A DIURETICS, URICOSURICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1988-03-01 US disclosed
US-4673746-A DIURETICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1987-06-16 US disclosed