Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 13/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10532110 | 0.94 | CYP19A1 (0.70) | CYP19A1KDM4EACHELMNAHTR1A | |
| SCHEMBL10530943 | 0.92 | CYP19A1 (0.71) | CYP19A1KDM4EACHEHTR1ADRD2 | |
| SCHEMBL10532311 | 0.91 | CYP19A1 (0.69) | CYP19A1KDM4EACHEHTR1ADRD2 | |
| SCHEMBL10530976 | 0.91 | CYP19A1 (0.69) | CYP19A1KDM4EACHEHTR1ADRD2 | |
| SCHEMBL10532377 | 0.90 | CYP19A1 (0.67) | CYP19A1KDM4EALDH1A1MAPTACHE | |
| SCHEMBL10532346 | 0.84 | CYP19A1 (0.70) | CYP19A1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL10651121 | 0.84 | CYP19A1 (0.70) | CYP19A1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL10532173 | 0.83 | CYP19A1 (0.65) | CYP19A1KDM4EALDH1A1MAPTACHE | |
| SCHEMBL2347624 | 0.82 | CYP19A1 (1.00) | CYP19A1 | |
| SCHEMBL10530061 | 0.81 | CYP19A1 (0.70) | CYP19A1KDM4EALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114033-B1 | SUBSTITUTED AZABICYCLOALKANES, THEIR USE, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THESE COMPOUNDS | CIBA-GEIGY AG (CH) | 1988-10-12 | — | — | EP | disclosed |
| EP-0114033-A1 | Substituted azabicycloalkanes, their use, pharmaceutical preparations containing these compounds and process for preparing these compounds | CIBA-GEIGY AG (CH) | 1984-07-25 | — | — | EP | disclosed |