SCHEMBL1066601

SCHEMBL1066601

O[SiH2]C=Cc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.50
LMNA P02545 3/20 0.46
ALDH1A1 P00352 2/20 0.46
HDAC3 O15379 2/20 0.46
HDAC4 P56524 2/20 0.46
HDAC1 Q13547 2/20 0.46
HDAC2 Q92769 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
HDAC6 Q9UBN7 2/20 0.46
PLIN1 O60240 2/20 0.46
MAPT P10636 2/20 0.46
RECQL P46063 2/20 0.46
PLIN5 Q00G26 2/20 0.46
ABHD5 Q8WTS1 2/20 0.46
TNKS O95271 1/20 0.46
HCAR2 Q8TDS4 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC11 Q96DB2 1/20 0.46
TNKS2 Q9H2K2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL355020 0.79 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL29076631 0.78 MAOB (0.55) MAOBLMNAALDH1A1HDAC3HDAC4
(Z)-1,2-Diphenylethene SCHEMBL29134000 0.76 MAOB (0.69) MAOBLMNAALDH1A1HDAC3HDAC4
(Z)-1,2-Diphenylethene SCHEMBL10418667 0.76 MAOB (0.69) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL5617360 0.74 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL8072802 0.74 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL5617362 0.74 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL9202420 0.74 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
SCHEMBL8845315 0.74 MAOB (0.50) MAOBLMNAALDH1A1HDAC3HDAC4
(Z)-1,2-Diphenylethene SCHEMBL443 0.73 MAOB (0.73) MAOBLMNAALDH1A1HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4155864-A ENDCAPPED POLYDIMETHYLSILOXANE AND MINOR AMOUNT OF ANOTHER POLYSILOXANE; DIELECTRIC FLUIDS IN ELECTRICAL APPARATUS UNION CARBIDE CORPORATION (US) 1979-05-22 US claimed
EP-2104718-B1 ADHESIVE SILICONE COMPOSITION AND ADHESION METHOD USING THE SAME BLUESTAR SILICONES FRANCE (FR) 2016-10-26 EP disclosed
US-8431647-B2 Adhesive silicone compositions and adhesive bonding/seaming therewith BLUESTAR SILICONES FRANCE SAS (FR) 2013-04-30 US disclosed
EP-1661960-B1 COATING COMPOSITION AND LOW DIELECTRIC SILICEOUS MATERIAL PRODUCED BY USING SAME AZ ELECTRONIC MATERIALS USA (US) 2012-07-25 EP disclosed
US-20110018235-A1 ADHESIVE SILICONE COMPOSITION AND ADHESION METHOD USING THE SAME BLUESTAR SILICONES FRANCE (FR) 2011-01-27 US disclosed
US-7754003-B2 Coating composition and low dielectric siliceous material produced by using same AZ ELECTRONIC MATERIALS USA CORP. (US) 2010-07-13 US disclosed
EP-2104718-A2 ADHESIVE SILICONE COMPOSITION AND ADHESION METHOD USING THE SAME Bluestar Silicones France (FR) 2009-09-30 EP disclosed
WO-2008080791-A2 ADHESIVE SILICONE COMPOSITION AND ADHESION METHOD USING THE SAME BLUESTAR SILICONES FRANCE (FR) 2008-07-10 WO disclosed
WO-2007045692-A1 SILICON RUBBER COMPOSITION WITH AN IMPROVED RESISTANCE TO FURTHER TEARING GE BAYER SILICONES GMBH & CO. KG (DE) 2007-04-26 WO disclosed
US-20060246303-A1 Coating composition and low dielectric siliceous material produced by using same MERCK PATENT GMBH (DE) 2006-11-02 US disclosed
EP-1661960-A1 COATING COMPOSITION AND LOW DIELECTRIC SILICEOUS MATERIAL PRODUCED BY USING SAME AZ Electronic Materials USA Corp. (US) 2006-05-31 EP disclosed
EP-0633171-B1 Windshield de-icing and defrosting apparatus using microwave energy heating and method JMK INT INC (US) 1998-01-21 EP disclosed
EP-0633171-A1 Windshield de-icing and defrosting mitt using microwave energy heating and method JMK International Inc. (US) 1995-01-11 EP disclosed
US-5369257-A Cured microwave heated layer with curing catalyst, particles and insulating fabrics JMK INTERNATIONAL, INC. (US) 1994-11-29 US disclosed
US-4552688-A M/ BON, PLATINUM TOSHIBA SILICONE CO., LTD. (JP) 1985-11-12 US disclosed
US-4419474-A CYANOGUANIDINE OR ARYLGUANIDINE BAYER AKTIENGESELLSCHAFT (DE) 1983-12-06 US disclosed
US-4155864-A ENDCAPPED POLYDIMETHYLSILOXANE AND MINOR AMOUNT OF ANOTHER POLYSILOXANE; DIELECTRIC FLUIDS IN ELECTRICAL APPARATUS UNION CARBIDE CORPORATION (US) 1979-05-22 US disclosed
US-4145505-A BIS(O-CHLOROBENZOYL)PEROXIDE AS CROSSLINKER AKZONA INCORPORATED (US) 1979-03-20 US disclosed
US-4138387-A Poly(olefinic monomer) filled-poly(organosiloxane) compositions GENERAL ELECTRIC COMPANY (US) 1979-02-06 US disclosed