Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Edetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.54 |
| ▸ | EYA2 | O00167 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Edetic Acid SCHEMBL28115154 | 0.94 | TDP1 (0.61) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL10355360 | 0.93 | TDP1 (0.47) | TDP1EYA2APPACELMNA | |
| Pentetic Acid SCHEMBL4302880 | 0.92 | TDP1 (0.62) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL22500519 | 0.92 | TDP1 (0.58) | TDP1EYA2APPACELMNA | |
| Acetic Acid SCHEMBL2464193 | 0.89 | TDP1 (0.46) | TDP1EYA2APPACELMNA | |
| SCHEMBL10385583 | 0.88 | TDP1 (0.52) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL19100098 | 0.87 | TDP1 (0.52) | TDP1EYA2APPACELMNA | |
| Edetic Acid SCHEMBL13735825 | 0.87 | TDP1 (0.52) | TDP1EYA2APPACELMNA | |
| SCHEMBL9714346 | 0.86 | TDP1 (0.50) | TDP1EYA2APPACELMNA | |
| SCHEMBL8968772 | 0.86 | TDP1 (0.50) | TDP1EYA2APPACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4791730-B2 | — | — | 2011-10-12 | — | — | JP | claimed |
| US-20060153804-A1 | Nucleic acid coated particles | POWDERJECT RESEARCH LIMITED | 2006-07-13 | — | — | US | claimed |
| EP-1545593-A1 | NUCLEIC ACID COATED PARTICLES | PowderJect Research Limited (GB) | 2005-06-29 | — | — | EP | claimed |
| WO-2004028560-A1 | NUCLEIC ACID COATED PARTICLES | POWDERJECT RESEARCH LIMITED (GB) | 2004-04-08 | — | — | WO | claimed |
| US-4839273-A | ANTIFUNGAL WATER TREATMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1989-06-13 | — | — | US | claimed |
| US-8349364-B2 | Nucleic acid coated particles suitable for temporary storage | POWDERJECT RESEARCH LIMITED (GB) | 2013-01-08 | — | — | US | disclosed |
| US-8012932-B2 | Contacting male ejaculate, prior to contact with a female egg, with an effective anti-fertility amount of a pharmaceutical composition, which comprises an antibody that binds a surface exposed epitope of SP22, and a pharmaceutically acceptable carrier | U.S. ENVIRONMENTAL PROTECTION AGENCY (US) | 2011-09-06 | — | — | US | disclosed |
| US-20110020350-A1 | Contraceptives Based on SP22 and SP22 Antibodies | KLINEFELTER GARY R | 2011-01-27 | — | — | US | disclosed |
| CN-1887293-A | Slimming composition with cross-linked monosaccharide/disaccharide and dietary fiber | NIU RONG (CN) | 2007-01-03 | — | — | CN | disclosed |
| US-20060153804-A1 | Nucleic acid coated particles | POWDERJECT RESEARCH LIMITED | 2006-07-13 | — | — | US | disclosed |
| EP-1545593-A1 | NUCLEIC ACID COATED PARTICLES | PowderJect Research Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004028560-A1 | NUCLEIC ACID COATED PARTICLES | POWDERJECT RESEARCH LIMITED (GB) | 2004-04-08 | — | — | WO | disclosed |