Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 13/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10668460 | 0.87 | PDE3B (0.41) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10648123 | 0.85 | KMT2A (0.39) | PDE3BPDE3ANPC1RAB9AKMT2A | |
| SCHEMBL10665307 | 0.85 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7313141 | 0.83 | PDE3B (0.37) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7313605 | 0.80 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7321069 | 0.80 | PDE4A (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7311174 | 0.77 | PDE4A (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7313145 | 0.77 | PDE4A (0.43) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10649421 | 0.74 | PDE3B (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10649789 | 0.72 | NPC1 (0.38) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761416-A | ENZYME INHIBITORS, INOTROPIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-08-02 | — | — | US | disclosed |