Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4386868 | 0.88 | KDM4E (0.60) | HRH3KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL26985810 | 0.86 | KDM4E (0.70) | HRH3KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30831555 | 0.86 | KDM4E (0.70) | HRH3KCNH2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10689006 | 0.86 | HRH2 (0.61) | HRH3 | |
| SCHEMBL5288663 | 0.86 | HRH2 (0.61) | HRH3 | |
| SCHEMBL10679839 | 0.86 | HRH2 (0.61) | HRH3 | |
| SCHEMBL30597717 | 0.86 | HRH2 (0.61) | HRH3 | |
| SCHEMBL10527698 | 0.86 | HRH2 (0.61) | HRH3 | |
| SCHEMBL9551700 | 0.85 | HRH2 (0.59) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9574750 | 0.82 | HRH2 (0.61) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738969-A | Substituted aminopyridones and aminoquinolones having histamine H2 -receptor blocking activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-19 | — | — | US | disclosed |
| US-4608380-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-08-26 | — | — | US | disclosed |