⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1816998 | 1.00 | — | — | |
| SCHEMBL127598 | 1.00 | — | — | |
| SCHEMBL9363401 | 0.76 | — | — | |
| SCHEMBL996066 | 0.74 | — | — | |
| SCHEMBL1133793 | 0.70 | — | — | |
| SCHEMBL17593334 | 0.70 | — | — | |
| SCHEMBL1252971 | 0.70 | — | — | |
| SCHEMBL703454 | 0.70 | — | — | |
| SCHEMBL246071 | 0.70 | — | — | |
| SCHEMBL9180817 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064178-A1 | HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2024-03-28 | — | — | WO | claimed |
| CN-107428762-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | claimed |
| CN-107074874-B | ERK inhibitor | 伊莱利利公司 | 2019-04-23 | — | — | CN | claimed |
| EP-3237420-B1 | ERK INHIBITORS | LILLY CO ELI (US) | 2018-09-26 | — | — | EP | claimed |
| US-9879029-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2018-01-30 | — | — | US | claimed |
| CN-107428762-A | Phthalazinone derivatives, preparation method and the usage | 四川科伦博泰生物医药股份有限公司 | 2017-12-01 | — | — | CN | claimed |
| EP-3237420-A1 | ERK INHIBITORS | Eli Lilly and Company (US) | 2017-11-01 | — | — | EP | claimed |
| US-20170267691-A1 | ERK INHIBITORS | LILLY CO ELI (US) | 2017-09-21 | — | — | US | claimed |
| CN-107074874-A | Erk inhibitor | 伊莱利利公司 | 2017-08-18 | — | — | CN | claimed |
| WO-2016106009-A1 | ERK INHIBITORS | ELI LILLY AND COMPANY (US) | 2016-06-30 | — | — | WO | claimed |
| US-12030903-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2024-07-09 | — | — | US | disclosed |
| WO-2024064178-A1 | HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2024-03-28 | — | — | WO | disclosed |
| CN-116848113-A | Bicyclic compounds as HPK1 inhibitors and application thereof | 南京再明医药有限公司 | 2023-10-03 | — | — | CN | disclosed |
| EP-4229050-A1 | HETEROCYCLIC GLP-1 AGONISTS | Gasherbrum Bio, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4106876-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-12-28 | — | — | EP | disclosed |
| CN-1181080-C | Dimethosilyl trialkylamine | CK韦特科公司 | 2004-12-22 | — | — | CN | disclosed |
| CN-1272498-A | Dimethosilyl trialkylamine | CK WEIGHTKE CO (US) | 2000-11-08 | — | — | CN | disclosed |
| EP-0262809-B1 | Pyrimidinylphenyl ester compound | TEIKOKU CHEM IND CO LTD (JP) | 1994-05-11 | — | — | EP | disclosed |
| US-4980082-A | DISPLAY ELEMENTS; HIGH SPEED RESPONSE TO ELECTRICAL FIELDS | SEIKO INSTRUMENTS INC. (JP) | 1990-12-25 | — | — | US | disclosed |
| EP-0262809-A1 | Pyrimidinylphenyl ester compound | TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) | 1988-04-06 | — | — | EP | disclosed |