Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | F3 | P13726 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1066523 | 0.92 | HDAC1 (0.64) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL4580090 | 0.89 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL4580183 | 0.89 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL4582008 | 0.85 | HDAC1 (0.59) | HDAC1HDAC3HDAC2HDAC8HDAC4 | |
| SCHEMBL148310 | 0.83 | HDAC1 (0.65) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL4579365 | 0.81 | HDAC1 (0.51) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL1066960 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL1066520 | 0.78 | HDAC1 (0.83) | HDAC1HDAC3HDAC2HDAC8KCNH2 | |
| SCHEMBL4577475 | 0.78 | HDAC1 (0.44) | HDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL3645718 | 0.76 | HDAC1 (0.81) | HDAC1HDAC3HDAC2HDAC8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868205-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | METHYLGENE, INC. (CA) | 2008-06-05 | — | — | US | disclosed |
| EP-1663953-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005030705-A9 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2006-04-20 | — | — | WO | disclosed |
| WO-2005030704-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |
| WO-2005030705-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132459-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC1 1/4885HDAC3 3/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.