Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.62 |
| ▸ | SYK | P43405 | 1/20 | 0.61 |
| ▸ | MLYCD | O95822 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4930583 | 0.87 | NPC1 (0.64) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL24440484 | 0.84 | HDAC6 (0.60) | POLBKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL29633482 | 0.84 | HDAC6 (0.60) | POLBKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4930568 | 0.83 | HSP90AA1 (0.61) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL18619400 | 0.82 | HDAC6 (0.58) | NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL3225126 | 0.82 | NPC1 (1.00) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL5988764 | 0.82 | HSP90AA1 (0.60) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL5989428 | 0.82 | HSP90AA1 (0.67) | NPC1RAB9APOLBKDM4EALDH1A1 | |
| SCHEMBL11094833 | 0.81 | ERCC1 (0.71) | RAB9AALDH1A1HPGDHSD17B10SYK | |
| SCHEMBL2956025 | 0.81 | NPC1 (0.68) | NPC1RAB9APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725598-A | Derivative of dihydroxybenzamide and a pharmaceutical composition having an anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1988-02-16 | — | — | US | claimed |
| EP-0142241-B1 | DIHYDROXYBENZAMIDE DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1987-12-02 | — | — | EP | claimed |
| EP-0142241-A1 | Dihydroxybenzamide derivatives having anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-05-22 | — | — | EP | claimed |
| EP-0142241-A1 | Dihydroxybenzamide derivatives having anti-inflammatory activity | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1985-05-22 | — | — | EP | disclosed |