Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MYLK | Q15746 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681934 | 0.92 | RXFP1 (0.48) | SMN1; SMN2NPSR1MAPK10RXFP1ALDH1A1 | |
| SCHEMBL10677381 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2NPSR1MAPK10RXFP1PARP1 | |
| SCHEMBL10678618 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPK10RXFP1PARP1 | |
| SCHEMBL10678626 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPK10RXFP1PARP1 | |
| SCHEMBL10672409 | 0.84 | KMT2A (0.51) | SMN1; SMN2NPSR1ALDH1A1MAPTPOLB | |
| SCHEMBL10680767 | 0.84 | CYP3A4 (0.50) | SMN1; SMN2NPSR1PARP1ALDH1A1MAPT | |
| SCHEMBL10676845 | 0.84 | MEN1 (0.51) | SMN1; SMN2ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL10680922 | 0.81 | KMT2A (0.57) | KMT2ACYP1A2ATMCYP2C19CA1 | |
| SCHEMBL10677678 | 0.80 | MEN1 (0.36) | SMN1; SMN2ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL10680214 | 0.80 | MEN1 (0.36) | SMN1; SMN2NPSR1ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | claimed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | claimed |
| US-4743611-A | TREATMENT OF DIABETIC COMPLICATIONS | AMERICAN HOME PRODUCTS CORP. (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0251784-A2 | Naphthalenylsulfonylimidazolidinediones and their thioxo analogs | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-01-07 | — | — | EP | disclosed |