Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10682633 | 1.00 | MAPT (0.43) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10685862 | 0.86 | KDM4E (0.43) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10685872 | 0.86 | KDM4E (0.43) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10567390 | 0.85 | KDM4E (0.39) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10567392 | 0.85 | KDM4E (0.39) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10690115 | 0.84 | MEN1 (0.43) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10684453 | 0.84 | MAPT (0.41) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10690121 | 0.84 | MEN1 (0.43) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10684449 | 0.84 | MAPT (0.41) | MAPTKDM4EALDH1A1MAPK1HTT | |
| SCHEMBL10684483 | 0.83 | KDM4E (0.43) | MAPTKDM4EALDH1A1MAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |