Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377298 | 0.91 | CHRM5 (0.48) | CHRM5ADRA2CACHESCN1ASCN4A | |
| SCHEMBL3844988 | 0.86 | CHRM5 (0.62) | CHRM5ADRA2CACHESIGMAR1SMN1; SMN2 | |
| SCHEMBL14661851 | 0.84 | CHRM5 (0.67) | CHRM5ADRA2CACHESIGMAR1SMN1; SMN2 | |
| SCHEMBL6384468 | 0.84 | CHRM5 (0.67) | CHRM5ADRA2CACHESIGMAR1SMN1; SMN2 | |
| SCHEMBL4516903 | 0.84 | CHRM5 (0.67) | CHRM5ADRA2CACHESIGMAR1SMN1; SMN2 | |
| SCHEMBL1786411 | 0.83 | CHRM5 (0.46) | CHRM5ADRA2CACHESCN1ASCN4A | |
| SCHEMBL9557378 | 0.82 | CHRM5 (0.62) | CHRM5ADRA2CACHEHRH3SMN1; SMN2 | |
| SCHEMBL23832668 | 0.81 | CHRM5 (0.40) | CHRM5ADRA2CACHESIGMAR1 | |
| SCHEMBL9557684 | 0.80 | CHRM5 (0.67) | CHRM5ADRA2CACHEHRH3SMN1; SMN2 | |
| SCHEMBL2227989 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4780478-A | Aminopropoxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) | 1988-10-25 | — | — | US | disclosed |
| US-4508732-A | Basic ethers useful as antidepressant agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-04-02 | — | — | US | disclosed |
| US-4376123-A | Hexahydroazepinyloxy-chromones useful as antidepressants | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-03-08 | — | — | US | disclosed |