Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ibuprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.70 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.70 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.70 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.70 |
| ▸ | ALB | P02768 | 1/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.70 |
| ▸ | RARB | P10826 | 1/20 | 0.70 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.70 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ibuprofen SCHEMBL1586498 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL18205062 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL465258 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL1179006 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL139269 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL5971384 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL30222251 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL9321827 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL8076351 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| Ibuprofen SCHEMBL42909 | 0.96 | CXCR1 (0.70) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4000602-A1 | NOVEL ZN(II)-NSAID-COMPLEX COMPOSITION | concrete flowers GmbH (AT) | 2022-05-25 | — | — | EP | claimed |
| CN-1215989-A | Dosage form of ibuprofen | BOOTS CO PLC (GB) | 1999-05-05 | — | — | CN | claimed |
| EP-4000602-A1 | NOVEL ZN(II)-NSAID-COMPLEX COMPOSITION | concrete flowers GmbH (AT) | 2022-05-25 | — | — | EP | disclosed |
| CN-104922084-B | Sodium ibuprofen tablet and method for preparing pharmaceutical composition containing sodium ibuprofen | 惠氏有限责任公司 | 2020-01-14 | — | — | CN | disclosed |
| CN-109851620-A | For inhibiting the condensed-bicyclic class compound of tyrosine kinase activity | 深圳市塔吉瑞生物医药有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-108368119-B | Fused Bicyclic Compounds for Inhibiting Tyrosine Kinase Activity | 深圳市塔吉瑞生物医药有限公司 | 2019-04-23 | — | — | CN | disclosed |
| CN-109384825-A | Plant steroid and application thereof | 戴维森洛佩兹有限责任公司 | 2019-02-26 | — | — | CN | disclosed |
| CN-104606160-B | A kind of fenoprofen calcium medicine compound | KAMP PHARMACEUTICALS CO., LTD. (CN) | 2018-06-01 | — | — | CN | disclosed |
| US-20170319518-A1 | Sodium Ibuprofen Tablets and Methods of Manufacturing Pharmaceutical Compositions Including Sodium Ibuprofen | WYETH LLC (US) | 2017-11-09 | — | — | US | disclosed |
| EP-2445486-B1 | SODIUM IBUPROFEN TABLETS AND METHODS OF MANUFACTURING PHARMACEUTICAL COMPOSITIONS INCLUDING SODIUM IBUPROFEN | WYETH LLC (US) | 2017-11-08 | — | — | EP | disclosed |
| CN-102858307-B | Soluble membranes containing high concentrations of nonionic surfactants such as polysorbates to enhance high solids loading | 高露洁-棕榄公司 | 2017-08-04 | — | — | CN | disclosed |
| US-20030045580-A1 | Ibuprofen containing active agent preparation | BASF AKTIENGESELLSCHAFT (DE) | 2003-03-06 | — | — | US | disclosed |
| CN-1400896-A | Ibuprofen containing active agent preparation | BASF AG (DE) | 2003-03-05 | — | — | CN | disclosed |
| CN-1321084-A | Pharmaceutical compositions comprising ibuprofen and domperidone | BOOTS CO PLC (GB) | 2001-11-07 | — | — | CN | disclosed |
| CN-1215989-A | Dosage form of ibuprofen | BOOTS CO PLC (GB) | 1999-05-05 | — | — | CN | disclosed |
| CN-1068734-A | THERAPEUTIC AGENT | BOOTS CO PLC (GB) | 1993-02-10 | — | — | CN | disclosed |
| EP-0346006-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING IBUPROFEN-CYCLODEXTRIN COMPLEXES | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0478838-A1 | Compositions containing ibuprofen and S-(+)-ibuprofen, and process to prepare them | PHARMATRANS SANAQ AG (CH) | 1992-04-08 | — | — | EP | disclosed |
| US-5019563-A | Pharmaceutical composition | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1991-05-28 | — | — | US | disclosed |
| EP-0346006-A1 | Pharmaceutical compositions containing ibuprofen-cyclodextrin complexes | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1989-12-13 | — | — | EP | disclosed |