Diphenylether

Diphenylether

SCHEMBL10690245

COC(=O)c1ccccc1.c1ccc(Oc2ccccc2)cc1

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.79
RAB9A P51151 4/20 0.62
MAPT P10636 3/20 0.62
SMN1; SMN2 Q16637 4/20 0.57
NPC1 O15118 2/20 0.57
L3MBTL1 Q9Y468 2/20 0.56
CASP3 P42574 1/20 0.56
SENP8 Q96LD8 1/20 0.56
SENP7 Q9BQF6 1/20 0.56
SENP6 Q9GZR1 1/20 0.56
CA1 P00915 2/20 0.55
CA2 P00918 2/20 0.55
AKR1C3 P42330 1/20 0.55
HPGD P15428 2/20 0.55
PGR P06401 1/20 0.55
ALDH1A1 P00352 2/20 0.54
GAA P10253 1/20 0.54
SLC6A3 Q01959 1/20 0.53
HDAC8 Q9BY41 1/20 0.53
PTPN1 P18031 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5608453 0.94 MAPT (0.71) TSHRRAB9AMAPTSMN1; SMN2NPC1
SCHEMBL9242690 0.94 MAPT (0.71) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL29039896 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL29831725 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL29105567 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL1867855 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL28945661 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL7200 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL1332323 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1
Methyl Benzoate SCHEMBL28537345 0.89 TSHR (1.00) TSHRRAB9AMAPTSMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4743703-A Herbicidal 4-fluoroalkyl-4'-nitrodiphenyl ethers ROHM AND HAAS COMPANY (US) 1988-05-10 US disclosed