Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 5/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GALR3 | O60755 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10513010 | 0.99 | PDE3A (0.63) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL13111965 | 0.88 | PDE3A (0.65) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Bromide SCHEMBL10514097 | 0.87 | PDE3A (0.62) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10513746 | 0.86 | PDE3A (0.63) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10512967 | 0.86 | PDE3A (0.63) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Bromide SCHEMBL10512780 | 0.78 | PDE3A (0.59) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10514765 | 0.78 | PDE3A (0.61) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10571909 | 0.78 | PDE3A (0.67) | PDE3APDE4AHPGDBLMCYP3A4 | |
| SCHEMBL10512372 | 0.77 | PDE3A (0.60) | PDE3APDE4AHPGDBLMCYP3A4 | |
| Olprinone SCHEMBL19205852 | 0.76 | PDE3A (1.00) | PDE3APDE4AHPGDBLMCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4791203-A | CARDIOTONIC AGENTS | EISAI CO., LTD. (JP) | 1988-12-13 | — | — | US | claimed |