Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 7/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 6/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3444431 | 0.80 | MAPT (0.50) | POLBL3MBTL1KMT2AHPGDMAPT | |
| SCHEMBL29185140 | 0.80 | GSK3B (0.50) | POLBTHRBTHRAL3MBTL1KMT2A | |
| SCHEMBL4367730 | 0.77 | POLB (0.41) | POLBTHRBTHRAL3MBTL1KMT2A | |
| SCHEMBL1199489 | 0.75 | — | — | |
| SCHEMBL29185145 | 0.73 | POLB (0.38) | POLBTHRBTHRAL3MBTL1KMT2A | |
| SCHEMBL14546650 | 0.73 | — | — | |
| SCHEMBL5582086 | 0.72 | POLB (0.40) | POLBTHRBTHRAL3MBTL1KMT2A | |
| SCHEMBL21617942 | 0.70 | POLB (0.48) | POLBL3MBTL1KMT2AHPGDMAPT | |
| SCHEMBL1529532 | 0.69 | DAO (0.63) | HCAR3HCAR2KMT2AMAPTKDM4E | |
| SCHEMBL28736806 | 0.69 | DAO (0.53) | POLBPDE4DL3MBTL1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1337961-A | Heteroaryl amidines, methyl amidiues and guanidines as protease inhibitors | DIMENSIONAL PHARM INC (US) | 2002-02-27 | — | — | CN | disclosed |
| US-4722933-A | GLAUCOMA TREATMENT | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1988-02-02 | — | — | US | disclosed |