Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.69 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322779 | 0.87 | KDM4E (0.76) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL432503 | 0.87 | SLC2A1 (0.78) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL6331153 | 0.84 | AKR1B1 (0.67) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL29540916 | 0.84 | AKR1B1 (0.67) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL8115506 | 0.84 | SLC2A1 (0.73) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL24496704 | 0.83 | SLC2A1 (0.72) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL8827849 | 0.83 | AKR1B1 (0.78) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL8117451 | 0.83 | AKR1B1 (0.78) | AKR1B1SLC2A1KDM4EMAOBMAPT | |
| SCHEMBL10459171 | 0.82 | SLC2A1 (0.71) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 | |
| SCHEMBL4250015 | 0.82 | AKR1B1 (0.76) | AKR1B1SLC2A1KDM4EMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4761425-A | ANTIASTHMATICS; ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | MERCK FROSST CANADA, INC. (CA) | 1988-08-02 | — | — | US | disclosed |
| EP-0147217-A2 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1985-07-03 | — | — | EP | disclosed |