Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Loracarbef Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.66 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | SLC15A2 | Q16348 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Loracarbef Anhydrous SCHEMBL1819705 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL34153 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL9017047 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL12306378 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL235140 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL2453036 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL13457172 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL17530968 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL17530291 | 1.00 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10MAPTKMT2A | |
| Loracarbef Anhydrous SCHEMBL1229813 | 0.99 | KDM4E (0.67) | KDM4EALDH1A1HSD17B10MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4734494-A | MICROBIOCIDE INTERMEDIATES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1988-03-29 | — | — | US | disclosed |
| US-4335211-A | PREFERENTIAL ACYLATION OF 2-CARBOXY-)-AMINO-8-OXO-1-AZA BICYLO/4.2.0/ OCT-2-ENE; CULTURES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-06-15 | — | — | US | disclosed |
| US-4302541-A | Process of producing optically active cephalosporin analogs by enzyme selective deacylation | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1981-11-24 | — | — | US | disclosed |