Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686264 | 0.90 | ENPP1 (0.45) | ENPP1BRD4FGFR1FGFR2PDE5A | |
| SCHEMBL10691876 | 0.83 | PDE2A (0.55) | ENPP1FGFR1FGFR2PDE5ASRC | |
| SCHEMBL10688379 | 0.80 | FGFR1 (0.45) | ENPP1FGFR1FGFR2PDE5ASRC | |
| SCHEMBL10691270 | 0.80 | FGFR1 (0.44) | ENPP1BRD4FGFR1FGFR2PDE5A | |
| SCHEMBL10688935 | 0.79 | FGFR1 (0.43) | ENPP1BRD4FGFR1FGFR2PDE5A | |
| SCHEMBL10688023 | 0.78 | FGFR1 (0.42) | ENPP1BRD4FGFR1FGFR2PDE5A | |
| SCHEMBL10686225 | 0.78 | MKNK1 (0.46) | ENPP1FGFR1FGFR2MKNK1MKNK2 | |
| SCHEMBL10693992 | 0.77 | TNNI3K (0.41) | ENPP1FGFR1FGFR2PDE5ASRC | |
| SCHEMBL10685682 | 0.77 | MAPT (0.45) | ENPP1FGFR1FGFR2PDE5ASRC | |
| SCHEMBL10746677 | 0.76 | PDE2A (0.67) | MKNK1MKNK2PDE5APDE2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4722929-A | Novel 2-phenyl-imidazoles and pharmaceutical compositions containing same | DR. KARL THOMAE GMBH (DE) | 1988-02-02 | — | — | US | disclosed |
| EP-0149200-A1 | Novel 2-pnenyl-imidazoles, their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1985-07-24 | — | — | EP | disclosed |