Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.46 |
| ▸ | PGR | P06401 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC22A6 | Q4U2R8 | 3/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 3/20 | 0.42 |
| ▸ | SLC22A11 | Q9NSA0 | 3/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10694488 | 0.92 | KMT2A (0.45) | NR1I2PGRPPARGESR1TDP1 | |
| Iodide SCHEMBL10693732 | 0.90 | KMT2A (0.44) | NR1I2PGRPPARGESR1TDP1 | |
| Iodide SCHEMBL10706366 | 0.90 | KMT2A (0.48) | NR1I2PGRPPARGESR1TDP1 | |
| Iodide SCHEMBL10695908 | 0.89 | KMT2A (0.55) | NR1I2PGRPPARGESR1TDP1 | |
| Iodide SCHEMBL10696502 | 0.88 | KMT2A (0.49) | NR1I2PGRPPARGESR1TDP1 | |
| Bromide SCHEMBL10835276 | 0.86 | NR1I2 (0.49) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL10835873 | 0.85 | NR1I2 (0.45) | NR1I2PGRPPARGESR1TDP1 | |
| Hydrochloric Acid SCHEMBL10385692 | 0.85 | KMT2A (0.45) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL9623431 | 0.84 | MAPT (0.57) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL10566033 | 0.84 | MAPT (0.57) | NR1I2PGRPPARGESR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4785090-A | ANTIBIOTICS, BACTERICIDES | MEIJI SEIKA KAISHA, LTD. (JP) | 1988-11-15 | — | — | US | disclosed |
| EP-0153709-A2 | Novel cephalosporin derivatives | MEIJI SEIKA KAISHA LTD. (JP) | 1985-09-04 | — | — | EP | disclosed |