Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzodiazepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzodiazepine SCHEMBL11469198 | 0.95 | MAPT (0.36) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Benzodiazepine SCHEMBL14740757 | 0.93 | MAPT (0.35) | MAPTGAAMAPK1 | |
| Benzodiazepine SCHEMBL29151800 | 0.93 | MAPT (0.35) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Benzodiazepine SCHEMBL4971764 | 0.91 | MAPT (0.36) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Benzodiazepine SCHEMBL27786695 | 0.91 | MAPT (0.36) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Benzodiazepine SCHEMBL1574261 | 0.91 | MAPT (0.36) | MAPTGAARAB9ASMN1; SMN2P2RX4 | |
| Benzodiazepine SCHEMBL28436814 | 0.91 | GAA (0.41) | MAPTGAA | |
| Benzodiazepine SCHEMBL7160172 | 0.91 | GAA (0.44) | MAPTGAA | |
| Benzodiazepine SCHEMBL8137 | 0.91 | GAA (0.44) | MAPTGAA | |
| Benzodiazepine SCHEMBL5332062 | 0.90 | HCAR2 (0.34) | MAPTGAAKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106232719-A | Highly heat-resistant polycarbonate compositions | 沙特基础工业全球技术有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-105849171-A | Interior train components having low smoke and low heat release, and methods of their manufacture | 沙特基础工业全球技术有限公司 | 2016-08-10 | — | — | CN | disclosed |
| EP-0255028-A2 | 1,4-Benzodiazepines, their preparation and use as PAF antagonists | BOEHRINGER INGELHEIM KG (DE) | 1988-02-03 | — | — | EP | disclosed |