Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | STAT1 | P42224 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.44 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13341481 | 0.96 | AURKA (0.45) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL2488324 | 0.96 | AURKA (0.51) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL13341269 | 0.93 | AURKA (0.50) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL13341476 | 0.91 | SLC2A1 (0.42) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL10701197 | 0.90 | AURKA (0.57) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL10700220 | 0.89 | SLC2A1 (0.46) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL10700270 | 0.89 | AURKA (0.47) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL13341494 | 0.89 | AURKA (0.49) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 | |
| SCHEMBL10696394 | 0.87 | PDE4A (0.52) | AURKAAURKBNPC1SMN1; SMN2RAB9A | |
| SCHEMBL13341472 | 0.87 | SLC2A1 (0.43) | AURKAAURKBSLC2A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |