Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10697084 | 0.95 | MEN1 (0.40) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL10695690 | 0.87 | MEN1 (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL10698656 | 0.86 | BRD4 (0.46) | MEN1KMT2APKMCA12CA1 | |
| SCHEMBL10700878 | 0.86 | POLB (0.40) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL10709508 | 0.85 | DHODH (0.41) | MEN1KMT2APKMCA12CA1 | |
| SCHEMBL10697337 | 0.84 | BRD4 (0.37) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL10695172 | 0.82 | MEN1 (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL10697806 | 0.82 | BRD4 (0.50) | MEN1KMT2APKMCA12CA1 | |
| SCHEMBL10700736 | 0.81 | BRD4 (0.41) | MEN1KMT2APKMCA12CA1 | |
| SCHEMBL10698013 | 0.77 | CA12 (0.50) | MEN1KMT2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |