Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9398051 | 0.84 | ACACB (0.60) | LTA4HACACB | |
| SCHEMBL5175359 | 0.80 | NPC1 (0.57) | NPC1RAB9AFFAR1LTA4HCA12 | |
| SCHEMBL27640951 | 0.78 | FFAR1 (0.55) | NPC1RAB9AFFAR1LTA4H | |
| SCHEMBL15831172 | 0.78 | NPC1 (0.56) | NPC1RAB9AFFAR1LTA4HCA12 | |
| SCHEMBL9456979 | 0.78 | NPC1 (0.80) | NPC1RAB9AFFAR1LTA4HCA12 | |
| SCHEMBL20429143 | 0.77 | NPC1 (0.58) | NPC1RAB9AFFAR1LTA4HCA12 | |
| SCHEMBL13140571 | 0.77 | FFAR1 (0.67) | NPC1RAB9AFFAR1LTA4HALDH1A1 | |
| SCHEMBL2839362 | 0.75 | HDAC3 (0.58) | NPC1RAB9AFFAR1LTA4HALDH1A1 | |
| SCHEMBL15000373 | 0.74 | FFAR1 (0.55) | NPC1RAB9AFFAR1 | |
| SCHEMBL1070131 | 0.74 | NPC1 (0.73) | NPC1RAB9AFFAR1LTA4HCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279281-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1988-08-24 | — | — | EP | disclosed |